先天免疫系统
生物
脂滴
免疫
细胞内寄生虫
细胞器
免疫系统
细胞内
寄主(生物学)
抗菌肽
细胞生物学
微生物学
抗菌剂
免疫学
生态学
作者
Rémi Safi,Miguel Sánchez-Álvarez,Marta Bosch,Caroline Demangel,Robert G. Parton,Albert Pol
摘要
Microbes have developed many strategies to subvert host organisms, which, in turn, evolved several innate immune responses. As major lipid storage organelles of eukaryotes, lipid droplets (LDs) are an attractive source of nutrients for invaders. Intracellular viruses, bacteria, and protozoan parasites induce and physically interact with LDs, and the current view is that they "hijack" LDs to draw on substrates for host colonization. This dogma has been challenged by the recent demonstration that LDs are endowed with a protein-mediated antibiotic activity, which is upregulated in response to danger signals and sepsis. Dependence on host nutrients could be a generic "Achilles' heel" of intracellular pathogens and LDs a suitable chokepoint harnessed by innate immunity to organize a front-line defense. Here, we will provide a brief overview of the state of the conflict and discuss potential mechanisms driving the formation of the 'defensive-LDs' functioning as hubs of innate immunity.
科研通智能强力驱动
Strongly Powered by AbleSci AI