髓样
生物
单核细胞
免疫学
祖细胞
炎症
免疫系统
细胞生物学
电池类型
表型
髓系细胞
骨髓生成
干细胞
细胞
遗传学
基因
作者
Lai Guan Ng,Zhaoyuan Liu,Immanuel Kwok,Florent Ginhoux
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2023-04-26
卷期号:41 (1): 375-404
被引量:11
标识
DOI:10.1146/annurev-immunol-081022-113627
摘要
Myeloid cells are a significant proportion of leukocytes within tissues, comprising granulocytes, monocytes, dendritic cells, and macrophages. With the identification of various myeloid cells that perform separate but complementary functions during homeostasis and disease, our understanding of tissue myeloid cells has evolved significantly. Exciting findings from transcriptomics profiling and fate-mapping mouse models have facilitated the identification of their developmental origins, maturation, and tissue-specific specializations. This review highlights the current understanding of tissue myeloid cells and the contributing factors of functional heterogeneity to better comprehend the complex and dynamic immune interactions within the healthy or inflamed tissue. Specifically, we discuss the new understanding of the contributions of granulocyte-monocyte progenitor-derived phagocytes to tissue myeloid cell heterogeneity as well as the impact of niche-specific factors on monocyte and neutrophil phenotype and function. Lastly, we explore the developing paradigm of myeloid cell heterogeneity during inflammation and disease.
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