神经毒性
星形胶质细胞
槲皮素
人类免疫缺陷病毒(HIV)
化学
药理学
神经科学
医学
病毒学
生物
内科学
生物化学
毒性
中枢神经系统
抗氧化剂
作者
Pengwei Huang,Jie Chen,Jinhu Zou,Xuefeng Gao,Hong Cao
出处
期刊:PubMed
[National Institutes of Health]
日期:2025-02-20
卷期号:45 (2): 304-312
标识
DOI:10.12122/j.issn.1673-4254.2025.02.11
摘要
Quercetin mitigates HIV-1 gp120-induced astrocyte neurotoxicity and cognitive function impairment by inhibiting oxidative stress, enhancing expressions of SG depolymerization-related proteins, and promoting SG disassembly, suggesting the value of quercetin as a potential therapeutic agent for neuroprotection in HIV-associated neurocognitive disorders.
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