小胶质细胞
神经炎症
神经科学
医学
机制(生物学)
中枢神经系统
神经毒性
神经认知
炎症
认知
免疫学
生物
内科学
毒性
认识论
哲学
作者
Yingli Yang,Wenxin Hang,Jun Li,Tiantian Liu,Yuhan Hu,Fuquan Fang,Dandan Yan,Patrick McQuillan,Mi Wang,Zhiyong Hu
标识
DOI:10.14336/ad.2023.1108
摘要
The effects of general anesthetic agents (GAAs) on microglia and their potential neurotoxicity have attracted the attention of neuroscientists. Microglia play important roles in the inflammatory process and in neuromodulation of the central nervous system. Microglia-mediated neuroinflammation is a key mechanism of neurocognitive dysfunction during the perioperative period. Microglial activation by GAAs induces anti-inflammatory and pro-inflammatory effects in microglia, suggesting that GAAs play a dual role in the mechanism of postoperative cognitive dysfunction. Understanding of the mechanisms by which GAAs regulate microglia may help to reduce the incidence of postoperative adverse effects. Here, we review the actions of GAAs on microglia and the consequent changes in microglial function. We summarize clinical and animal studies associating microglia with general anesthesia and describe how GAAs interact with neurons via microglia to further explore the mechanisms of action of GAAs in the nervous system.
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