Interaction of Nanomaterials with Protein-Peptide

Abstract: Nanomaterials have undergone rapid development in the last few decades, galvanized by the versatility of their functional attributes and many inherent advantages over bulk materials. The state of art experimental techniques to synthesize nanoparticles (NPs) from varied sources, offers unprecedented opportunities for utilization and exploration of multifaceted biological activities. Such formulations demand preliminary understanding of the interaction between NPs and biomolecules. Most of these interactions are dependent on the external morphology of the NPs, like the shape, size, charge and surface chemistry. In addition, majority of the experimental techniques are limited to cellular level data, without the atomistic details of mechanisms that lead to these interactions. Consequently, recent studies have determined these atomistic events through in-silico techniques, which provides better understanding and integrative details of interactions between biomolecules and different NPs. Therefore, while delineating the protein-NPs interaction, it is imperative to define the consequences of nanomaterial’s introduction and derive data for formulation of better therapeutic interventions. This review briefly discusses varied types of NPs, their potential applications and interactions with peptide and proteins.