Identifying an Early Neuropathological Mechanism in Schizophrenia With Brain Organoids

SEE CORRESPONDING ARTICLE ON PAGE 687 Longitudinal Transcriptomic Analysis of Human Cortical Spheroids Identifies Axonal Dysregulation in the Prenatal Brain as a Mediator of Genetic Risk for SchizophreniaBiological PsychiatryVol. 95Issue 7PreviewSchizophrenia (SCZ) has a known neurodevelopmental etiology, but limited access to human prenatal brain tissue hampers the investigation of basic disease mechanisms in early brain development. Here, we elucidate the molecular mechanisms contributing to SCZ risk in a disease-relevant model of the prenatal human brain. Full-Text PDF Open Access