Photoredox‐Catalyzed Oxydifluoroalkylation of Styrenes for Access to Difluorinated Ketones with DMSO as an Oxidant

Abstract By taking advantage of dimethyl sulfoxide (DMSO) as an oxidant, the photoredox‐catalyzed alkene oxydifluoroalkylation for formal C(sp3)−CF2R and C(sp2)=O formation is disclosed for the first time. This difunctionalization reaction employs readily available styrenes as the substrates and bromodifluoro compounds as the difluoroalkylating reagents, which can afford the difluorinated ketones in acceptable yields with excellent regioselectivity. Experiments indicate that fac‐Ir(ppy)3‐catalyzed oxydifluoroalkylation can proceed smoothly under base‐free conditions in the presence of AgTFA. magnified image