化学
半乳糖氧化酶
酒精氧化
氧化还原
配体(生物化学)
分子内力
反应性(心理学)
催化作用
齿合度
铜
脱氢
非无辜配体
光化学
药物化学
晶体结构
高分子化学
立体化学
无机化学
有机化学
半乳糖
受体
生物化学
病理
替代医学
医学
作者
Khashayar Rajabimoghadam,Yousef Darwish,Umyeena Bashir,Dylan Pitman,Sidney Eichelberger,Maxime A. Siegler,Marcel Swart,Isaac Garcia‐Bosch
摘要
In this research article, we describe the structure, spectroscopy, and reactivity of a family of copper complexes bearing bidentate redox-active ligands that contain H-bonding donor groups. Single-crystal X-ray crystallography shows that these tetracoordinate complexes are stabilized by intramolecular H-bonding interactions between the two ligand scaffolds. Interestingly, the Cu complexes undergo multiple reversible oxidation–reduction processes associated with the metal ion (CuI, CuII, CuIII) and/or the o-phenyldiamido ligand (L2–, L•–, L). Moreover, some of the CuII complexes catalyze the aerobic oxidation of alcohols to aldehydes (or ketones) at room temperature. Our extensive mechanistic analysis suggests that the dehydrogenation of alcohols occurs via an unusual reaction pathway for galactose oxidase model systems, in which O2 reduction occurs concurrently with substrate oxidation.
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