Natural products as biofilm formation antagonists and regulators of quorum sensing functions: A comprehensive review update and future trends

Quorum sensing (QS) are defined as an entire set of bacterial behaviors: biofilm formation, bioluminescence, conjugation and virulence, antibiotic production, competence, conjugation, swarming, motility and sporulation. The present review foccuses on QS properties of bacteria and yeasts and influence of natural matrices on supression of QS function in pathogenic microorganisms. This review covers an update of scientific works, on products of natural origin as anti-QS agents. Plant, bacteria, fungi, sponge, and algae species and their isolated principal components, are highlighted as promising materials with high anti-QS capacities on various bacteria and yeasts. Special emphasis was given to anti-QS capacities of natural matrices on Pseudomonas aeruginosa, as one of the safest models systems for studies in the area of QS inhibition. Future trends in anti-QS drugs development are briefly discussed.