冠状动脉疾病
医学
心脏病学
1-磷酸鞘氨醇
再灌注损伤
心肌梗塞
炎症
内科学
缺血
鞘氨醇
受体
作者
Aynaz Mihanfar,Hamid Reza Nejabati,Amir Fattahi,Zeinab Latifi,Masoud Pezeshkian,Abbas Afrasiabi,Naser Safaie,Ahmadreza Jodati,Mohammad Nouri
摘要
Abstract Coronary artery disease (CAD) is a common cause of morbidity and mortality worldwide. Atherosclerotic plaques, as a hallmark of CAD, cause chronic narrowing of coronary arteries over time and could also result in acute myocardial infarction (AMI). The standard treatments for ameliorating AMI are reperfusion strategies, which paradoxically result in ischemic reperfusion (I/R) injury. Sphingosine 1 phosphate (S1P), as a potent lysophospholipid, plays an important role in various organs, including immune and cardiovascular systems. In addition, high‐density lipoprotein, as a negative predictor of atherosclerosis and CAD, is a major carrier of S1P in blood circulation. S1P mediates its effects through binding to specific G protein‐coupled receptors, and its signaling contributes to a variety of responses, including cardiac inflammation, dysfunction, and I/R injury protection. In this review, we will focus on the role of S1P in CAD and I/R injury as a potential therapeutic target.
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