Clinical evaluation of 40.68 MHz fractional unipolar radiofrequency-induced plasma for the treatment of rosacea

Rosacea is a chronic inflammatory dermatosis characterized by persistent facial erythema, telangiectasia, papules, pustules, and skin sensitivity.Although conventional therapies including oral medications, topical agents, pulsed dye laser, and intense pulsed light are widely used, recurrence and incomplete clinical response remain common.Fractional radiofrequency (FRF)-induced plasma has recently emerged as a potential therapeutic modality with anti-inflammatory, sebaceous-modulating, and dermal remodeling effects.To evaluate the clinical efficacy and safety of 40.68 MHz FRF-induced plasma treatment using the OPUS Plasma system in a patient with papulopustular rosacea.A 29-year-old female patient with papulopustular rosacea underwent two treatment sessions at 3-week intervals using a 40.68 MHz FRF-induced plasma device equipped with a 6-pin atrophic pixel roller tip.Treatment parameters including depth, power, rolling speed, contact pressure, and pass count were adjusted according to anatomical regions.Standardized clinical photography and skin analysis using the Mark-Vu imaging system were performed at baseline and follow-up visits.No concurrent oral medications, topical agents, or additional laser-based treatments were administered during the study period.Clinical improvement was observed after the first treatment session, including reduction of erythema, inflammatory papules, swelling, and skin sensitivity.Additional improvements in skin texture, pore appearance, and sebaceous activity were observed after the second treatment session.Downtime was limited to transient erythema, mild edema, soreness, and temporary roughness lasting less than 7 days.No blistering, pigmentary alteration, scarring, or worsening of rosacea symptoms was observed.FRF-induced 40.68 MHz plasma treatment demonstrated favorable clinical improvement and a satisfactory safety profile in a patient with papulopustular rosacea.The therapeutic effect may be associated with sebaceous gland modulation, dermal remodeling, vascular stabilization, and plasma-mediated anti-inflammatory activity.FRF-induced plasma may represent a promising adjunctive or alternative treatment option for rosacea, particularly in patients with recurrent or treatment-resistant disease.