Electrodermal activity and its molecular mechanisms: Unraveling insights into skin diseases

<p>Electrodermal activity (EDA) refers to the changes in electrical potential recorded on the skin surface, which mainly reflect the electrical properties of the skin and sympathetic nerve activity reflected by sweat secretion. Various dermatoses impair the skin barrier and alter the function of innervated nerves, resulting in significant fluctuations in EDA. This manuscript aims to provide a comprehensive overview of the molecular mechanisms underlying representative skin symptoms related to inflammation, fibrosis, and sweat gland disorders, and to explore the correlation of these mechanisms with EDA components. The physiological significance of EDA is discussed to provide a new perspective for the clinical application of EDA.</p>