化学
酰胺
微管蛋白
血管内皮生长因子受体
药理学
癌症研究
组合化学
立体化学
生物化学
微管
细胞生物学
医学
生物
作者
Zhenling Liu,S.-Y. Mao,Huixia Li,Wei Liu,Jing Tao,Yuebing Lu,Hui Dong,Jie Zhang,Chuanjun Song,Yongtao Duan,Yongfang Yao
标识
DOI：10.1016/j.bioorg.2024.107679
摘要
Dual-target agents have more advantages than drug combinations for cancer treatment. Here, we designed and synthesized a series of novel VEGFR-2/tubulin dual-target inhibitors through a molecular hybridization strategy, and the activities of all the synthesized compounds were tested against tubulin and VEGFR-2. Among which, compound 19 exhibited strong potency against tubulin and VEGFR-2, with IC
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