Inexpensive Benchtop Soft Photolithography Technique for Microfluidics and Other Applications

Microfluidics have emerged as a vital tool in various scientific and engineering applications, ranging from biomedical diagnostics to chemical analysis. However, conventional fabrication methods often necessitate costly equipment and limiting accessibility, thereby hindering widespread adoption. In response, this note presents a cost-effective approach for fabricating microfluidic channels using photolithographic methods, which circumvents the need for expensive instruments. The procedure commences with the preparation of a suitable substrate, followed by the application of a photoresist layer. A photomask, containing the desired microfluidic pattern, is then used to define the layout on the photoresist-coated substrate. Upon exposure to ultraviolet (UV) light, the photoresist undergoes a chemical transformation, allowing for selective removal of either exposed or unexposed regions. Consequently, the patterned microfluidic channels are unveiled on the substrate. The versatility of this photolithographic method allows for the fabrication of intricate and customizable microchannels with relative ease and precision. Further processing steps, such as etching or surface treatment, optimize the substrate's properties for specific applications. This low cost approach not only empowers researchers and engineers to develop microfluidic devices at a fraction of the cost but also fosters broader access to photolithography related research and development. The enhanced accessibility opens doors to a myriad of applications, ranging from advanced diagnostics and drug delivery systems to portable point-of-care devices. Overall, this paper showcases a promising avenue for expanding the reach of microfluidics, fostering innovation, and driving impactful advancements in diverse scientific disciplines.