中毒性表皮坏死松解
卡马西平
科克伦图书馆
荟萃分析
医学
人口
汉族
人类白细胞抗原
不利影响
等位基因
传统医学
内科学
皮肤病科
遗传学
免疫学
基因
生物
基因型
精神科
癫痫
环境卫生
单核苷酸多态性
抗原
作者
Qiang Meng,Hong-Yan Gu,Qinghua Zhang,Zhao Yi,Dechun Jiang
出处
期刊:Pharmacogenomics
[Future Medicine]
日期:2023-06-01
卷期号:24 (8): 459-474
被引量:1
标识
DOI:10.2217/pgs-2023-0054
摘要
Aim: Examining the association between HLA-A/B alleles and different carbamazepine (CBZ)-induced cutaneous adverse reactions in the Chinese population. Methods: A systematic review and meta-analysis of case-control studies was conducted. A systematic search was conducted of PubMed, Embase, the Cochrane Library, National Knowledge Infrastructure, the Chinese Biomedical Literature database and Wanfang Digital Periodicals. Results: 23 studies with a total of 1174 patients were included. In the Han population, HLA-B*15:02 is significantly associated with the increased risk of CBZ-related Stevens-Johnson syndrome/toxic epidermal necrolysis, and this correlation was not related to geographic distribution. HLA-A*31:01, B*38:02 are associated with CBZ-related maculopapular eruption in South Han population. HLA-A*31:01 is associated with CBZ-DRESS in Taiwan Han population. Conclusion:HLA-B*15:02, A*31:01 and B*38:02 genes were found to be involved in the occurrence of CBZ cutaneous adverse reactions in Han Chinese.
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