二萜
立体化学
化学
二维核磁共振波谱
EC50型
化学结构
生物
生物化学
体外
有机化学
作者
Huiwen Shi,Xiufen Jiang,Liudan Cao,Xing Peng,Qingyun Tan,Xifeng Teng,Qiong Gu,Limin He
出处
期刊:Fitoterapia
[Elsevier]
日期:2023-04-01
卷期号:166: 105461-105461
被引量:1
标识
DOI:10.1016/j.fitote.2023.105461
摘要
Six new neoclerodane diterpenoids (1-6), along with ten known compounds (7-16), were isolated from Ajuga forrestii. Their structures were elucidated by HRESIMS, 1D and 2D NMR, ECD calculation, and single-crystal X-ray diffraction analysis. The structure of a known neoclerodane diterpene ajudecunoid C (6) was revised based on the reported NMR empirical rules. All the isolates were evaluated for their inhibitory effect on RSL3-induced ferroptosis in HT22 mouse hippocampal neuronal cells. Among them, compounds 8, 9, and 12 significantly inhibited RSL3-induced ferroptosis with EC50 values of 0.45 μM, 0.076 μM, and 0.14 μM.
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