Value of gastroscopy combined with serum pepsinogen in the diagnosis of high risk Hp related gastric cancer

Objective: To explore the value of Helicobacter pylori antibody (Hp-IgG) and serum \npepsinogen (PG) combined with gastroscopy for screening early gastric cancer and \nprecancerous lesions in high-risk groups, so as to provide references for early clinical \nprevention and diagnosis. Methods: A retrospective analysis of our hospital from December \n2014 to December 2017 were elderly patients with gastric cancer 304 cases, selected admitted \n122 cases of elderly patients with gastric precancerous lesion (divided into superficial gastritis \ngroup, 70 cases of chronic atrophic gastritis group 52 cases) and 156 cases to the hospital in \nhealthy volunteers as the control group. The status and the positive rate of Helicobacter pylori \n13C urea breath test and compared two groups of patients with infection; using enzyme-linked \nimmunosorbent assay of serum pepsinogen I (PG I), II (PG II) and pepsin Hp-IgG quantitative \nand qualitative diagnosis of individual and combined diagnostic efficiency and the comparison \nof three kinds of index. Results: The four groups were compared, the serum PG level of I from \nhigh to low were superficial gastritis group, normal control group, atrophic gastritis group \nand gastric cancer group, the differences were statistically significant; serum PG II levels \nfrom high to low in gastric cancer group and superficial gastritis group. Atrophic gastritis \ngroup, normal control group, the differences were statistically significant. Compared with the \nthree groups, the positive rate of Hp-IgG was 90.7% in the gastric cancer group, 45.6% in the \nsuperficial gastritis group, 52.5% in the atrophic gastritis group, and the gastric cancer group \nwas higher than that in the precancerous lesion group, but there was no difference between the \nprecancerous lesions group. In terms of diagnostic efficacy, the specificity and sensitivity of \nHelicobacter pylori combined with pepsinogen were higher than those of the single diagnosis. \nConclusion: Hp-IgG and PG combined with gastroscopy in screening high-risk gastric cancer \nand its precancerous lesions are of high specificity, high sensitivity and can be popularized in \nclinic.