罗格宁
化学
环烯醚萜
全合成
立体化学
对映选择合成
立体选择性
单体
糖苷
有机化学
高效液相色谱法
催化作用
聚合物
作者
Akiho Yoshidome,Jukiya Sakamoto,Mizuki Kohara,Shinya Shiomi,Mako Hokaguchi,Yuki Hitora,Mariko Kitajima,Sachiko Tsukamoto,Hayato Ishikawa
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-01-06
卷期号:25 (2): 347-352
被引量:2
标识
DOI:10.1021/acs.orglett.2c03965
摘要
Divergent total syntheses of the hetero-oligomeric iridoid glycosides mainly found in Dipsacus asper were achieved. Thus, loganin (1), which is important as a monomer unit, was efficiently synthesized by stereoselective reductive cyclization using secologanin (2) as a substrate. Sequential condensation reactions of derivatives of 1 and 2 as monomer units led to the first enantioselective total syntheses of the heterooligomers cantleyoside, (E)-aldosecologanin, dipsaperine, (3R, 5S)-5-carboxyvincosidic acid 22-loganin ester, and dipsanoside A.
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