Transcatheter tricuspid valve replacement (TTVR) is an emerging therapeutic option for high-surgical-risk patients with severe symptomatic tricuspid regurgitation (TR). This report presents 30-day clinical outcomes of the novel LuX-Valve Plus transjugular tricuspid valve replacement system in high-surgical-risk patients with severe TR who required large-size LuX-Valve (55mm, 60mm, 65mm or 70mm), a patient group for whom both treatment options and reported TTVR outcomes have been limited to date.