469-P: Direct Medical Costs Associated with Cardiovascular Complications for Adults with Type 2 Diabetes—Evidence from a U.S. Retrospective Study

Introduction: Cardiovascular (CV) disease is a major cause of morbidity and mortality for people with diabetes. This study examines the annual medical costs of newly identified CV complications for adults with type 2 diabetes (T2D). Methods: Optum’s de-identified Clinformatics® Data Mart data from 1/1/2015 - 6/30/2021 was used to examine a cohort of adults with T2D identified with a CV complication, with first such date identified as the index date. Descriptive statistics examined the direct medical costs (inpatient, emergency, and outpatient) associated with each complication in the 1st and 2nd year post index date. Complications included heart failure (HF), myocardial infarction (MI), stroke (STRK), hospitalization with a diagnosis of unstable angina (HUA), coronary revascularization (CR), and hypertension (HTN). Results: There were 167,046 patients with an average of 1.2 conditions of interest each. HTN (12.3%), STRK (12.1%), and HF (10.6%) were the most common complications. In the 1st year post index date, HUA, MI, and HF were the most expensive complications. In the 2nd year post index date, costs of each complication ranged from 1.7% (CR) to 65.0% (HTN) of 1st year costs (see Figure). Conclusion: Results illustrate the costs associated with CV-related complications for T2D and helps to quantify the economic burden that T2D imposes on U.S. healthcare systems. Disclosure J.P.Bae: None. V.Thieu: None. M.J.Lage: Consultant; Eli Lilly and Company. K.Boye: Employee; Eli Lilly and Company.