神经营养因子
内科学
超重
内分泌学
脑源性神经营养因子
医学
神经营养素
多发性硬化
血脑屏障
体育锻炼
神经生长因子
烯醇化酶
心理学
免疫学
体质指数
中枢神经系统
受体
免疫组织化学
作者
Motahare Mokhtarzade,Robert W. Motl,Raoof Negaresh,Philipp Zimmer,Mostafa Khodadoost,Julien S. Baker,Darpan I. Patel,Nastaran Majdinasab,R Ranjbar
出处
期刊:Neuropeptides
[Elsevier]
日期:2018-08-01
卷期号:70: 93-100
被引量:42
标识
DOI:10.1016/j.npep.2018.05.010
摘要
Blood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15). The intervention consisted of 8 weeks (3 days per week) of cycling undertaken at 60–70% peak power. Resting blood concentrations of s100 calcium-binding protein B (s100b) and neuron-specific enolase as BBB permeability markers, neurotrophic factors and cytokines (Interleukin-10 and tumor necrosis factor alpha) were evaluated before and after the intervention. There were significant weight, training, and interaction effects on brain-derived neurotrophic factor and platelet-derived growth factor; however, ciliary neurotrophic factor and nerve growth factor did not demonstrate any effect. Brain-derived neurotrophic factor and platelet-derived growth factor were significantly increased from pre-post in normal weight exercise. Significant weight, training, and interaction effects were found for s100b. In detail, s100b was significantly increased from pre-post in normal weight exercise. In contrast, neuron-specific enolase and cytokines did not demonstrate any effect. Generally, Exercise training may alter markers of BBB permeability and neurotrophic factor status in normal weight persons with multiple sclerosis; however, overweight participants may be more resistant to these effects of exercise.
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