接种疫苗
限制
免疫
医学
免疫学
免疫疗法
免疫系统
机械工程
工程类
作者
Beatriz M. Carreño,Michelle Becker-Hapak,Alexander C. Huang,Megan Chan,Amer Alyasiry,Wen-Rong Lie,Rebecca Aft,Lynn A. Cornelius,Kathryn Trinkaus,Gerald P. Linette
摘要
Background. Systemic administration of IL-12p70 has demonstrated clinical activity in cancer patients, but dose-limiting toxicities have hindered its incorporation in vaccine formulations. Here, we report on the immunological and clinical outcomes upon vaccination with CD40L/IFN-γ–matured, IL-12p70–producing DCs.
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