染色
医学
肾功能
肾
组织谷氨酰胺转胺酶
免疫组织化学
肾病
内科学
肌酐
病理
内分泌学
肾脏疾病
化学
糖尿病
生物化学
酶
作者
Ryota Ikee,Shuzo Kobayashi,Noriaki Hemmi,Takamitsu Saigusa,Tamehachi Namikoshi,Muneharu Yamada,Toshihiko Imakiire,Yasufumi Kikuchi,Shigenobu Suzuki,Soichiro Miura
出处
期刊:Nephron
[S. Karger AG]
日期:2007-01-16
卷期号:105 (3): c139-c146
被引量:29
摘要
<i>Background:</i> Transglutaminase (Tg)-2 is shown to be related to renal fibrosis. However, its roles in human kidney disease have not been fully studied. <i>Methods:</i> Using immunohistochemistry, we examined Tg-2 expression in renal biopsy specimens from 22 patients with IgA nephropathy (IgAN) and correlated the intensity of Tg-2 staining with clinical and histopathological parameters. We compared the distribution and intensity of Tg-2 staining with those of transforming growth factor (TGF)-β staining. <i>Results:</i> In normal human kidneys, Tg-2 staining was not significant. In IgAN kidneys, glomerular Tg-2 staining correlated with serum creatinine (S-Cr), creatinine clearance (Ccr), urinary protein excretion, glomerular sclerosis, and mesangial cell proliferation. Tubulointerstitial Tg-2 correlated with S-Cr, Ccr, <i>N</i>-acetyl-β-glucosaminidase, urinary β<sub>2</sub>-microglobulin, and tubulointerstitial injuries. Tg-2 staining in the vicinity of vascular poles of glomeruli preceded the development of mesangial lesions, and was more remarkable in cases with renal impairment. The distribution and intensity of Tg-2 staining were not consistent with those of TGF-β staining. In glomerular crescents, Tg-2 staining was remarkable. <i>Conclusion:</i> The present study showed a correlation between Tg-2 expression and renal function and pathological changes. Tg-2 expression in the vicinity of vascular poles was notable because that may be an initial marker of glomerular injury.
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