The Structure-function Relationships between Two Different Optical Coherence Tomography in Patients with High Myopic Glaucoma

Purpose: To evaluate the structure-function relationships between swept-source optical coherence tomography (SS-OCT) and spectral-domain optical coherence tomography (SD-OCT) in glaucoma patients with high myopia. Methods: Forty-three eyes with high-myopia (axial length over 28 mm) and 30 with emmetropia (axial length 21 to 24 mm) of patients with preperimetric glaucoma and primary open-angle glaucoma were retrospectively enrolled. Visual field (VF) sensitivity and mean deviation were evaluated via standard automated perimetry. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured using SD-OCT and SS-OCT. The topographic relationships between structure and function were investigated. Results: In the high myopia group, the average (p < 0.001) and all six sectorial (all p < 0.05) RNFL thicknesses on SS-OCT correlated significantly with the corresponding VF sensitivities. In high myopia patients, the average RNFL thickness did not correlate with the mean sensitivity (MS). SD-OCT revealed no significant sectorial structure-function relationships in four sections, but did in two sectors (both p > 0.05). The emmetropic group exhibited a significant correlation between the average RNFL thickness, and the MS and VF mean deviation (MD) using SS-OCT (both p 0.001). The average RNFL thickness correlated significantly with the MD using SD-OCT (p = 0.036). In emmetropia patients, the superotemporal, inferotemporal, superonasal, and inferonasal RNFL thicknesses correlated with the corresponding VF sensitivities using both SS-OCT and SD-OCT (all p < 0.05). Conclusions: SS-OCT assessed structure-function relationships more accurately than did SD-OCT in glaucoma patients with high myopia.