Clinical analysis of continuous blood purification in the treatment of severe sepsis in infants

Objective To investigate the clinical efficacy and safety of continuous blood purification (CBP) in the treatment of severe sepsis in infants. Methods A retrospective analysis of 40 infants with severe sepsis treated with CBP was performed at PICU of Hunan Children′s Hospital from January 2014 to July 2017, and 50 infants with severe sepsis who were not treated with CBP at the same period were enrolled as control group.The indicators included blood gas analysis, lactic acid (Lac), blood glucose, electrolytes, blood routine, C-reaction protein (CRP) and procalcitonin (PCT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total bilirubin(TB), urea nitrogen (BUN), serum creatinine (Scr) and creatine kinase isoenzyme MB (CK-MB), pediatric critical illness score (PCIS). Results (1) After 3 days of treatment, the recovery of body temperature, heart rate, respiratory rate and blood pressure in CBP group were better than those in the control group, and the differences between two groups were statistically significant(P 0.05). (5) Two cases of thrombocytopenia, 2 cases of femoral vein thrombosis, 2 cases of hypovolemic shock, and 1 case of blood coagulation in filter happened in CBP gruop, all cases had no puncture site infection. Conclusion CBP can improve the vital signs, internal environment, inflammatory reaction and organ function of infants with severe sepsis, and the effect is better than that of traditional methods.The complications of CBP in infants with severe sepsis are relatively large, so we should strictly master the indications of CBP in the treatment of severe sepsis in children. Key words: Continuous blood purification; Severe sepsis; Infants; Clinical efficacy; Safety