Objective To explore the impact of lifestyle intervention on knowledge,attitude and behavior of chronic diseases and their risk factors in rural residents.Methods Education and behavior intervention were performed for rural residents in the middle and western areas of Shandong province.A random sampling method was used for the effectiveness evaluation of intervention.Results The awareness rate of health knowledge was higher in intervention group than that in control group(P0.01).There were significant differences(20-40%) in attitudes toward the relationships between hypertension,hyperlipidemia and high levels of salt and fat intake.The salt and oil intakes were significantly lower in intervention group(11.18 and 32.72 g/person·d,respectively) than those in control(12.67 and 38.57 g/person·d,respectively)(P0.01).The intervention group had higher rates of healthy levels of salt and oil intakes(15.5% and 53.3%)than those in control group(9.4% and 36.6%).Conclusion The lifestyle intervention increased the awareness rates of healthy knowledge and chronic disease risks in rural residents.Continuous efforts of health education and health promotion activities should be given to rural residents.