Selective In Situ Growth of Programable Noble Metal Nanoclusters on DNA Origami

The ability to fabricate precisely patterned metal nanoclusters with nanoscale resolution is important for advancing applications in heterogeneous catalysis, biosensing, and nanoscale optical and electronic circuits. Here, we report a simple yet efficient approach for constructing metal nanoclusters with customized shapes on 2D DNA origami templates. Our approach leverages the regiospecific functionalization of DNA origami scaffolds with reactive chemical entities that serve as reduction centers for in situ synthesis of metal nanoclusters. We also demonstrate the hierarchical assembly of individual metallized DNA origami units into well‐defined higher‐order architectures. This work advances the development of DNA origami templated platforms for constructing programable, high‐resolution nanodevices in electronic and optical applications.