Metformin‐Based Covalent Organic Frameworks With Excellent Biosafety and High Efficiency against Pathogenic Microorganisms

>5000 mg/kg is confirmed. Mechanistic studies based on molecular dynamics (MD) simulation and transcriptome results revealed a triple synergistic antibacterial pathway involving membrane targeting, ROS attack, and metabolic interference. Furthermore, we fabricated a COF/thermoplastic polyurethane (TPU) composite functional membrane, which exhibits >99 % antibacterial and antiviral efficiency, along with a notable 98.3 % inhibition rate against methicillin-resistant Staphylococcus aureus (MRSA). This study not only provides a new design strategy for MCOFs with synergistically enhanced functionality and biosafety, but also offers a promising material platform for biomedical applications such as anti-infection protection, wound healing, and the treatment of drug-resistant bacterial infections.