胶束
药物输送
体内
化学
两亲性
阿霉素
药品
树枝状大分子
癌细胞
药理学
纳米技术
癌症
生物物理学
材料科学
化疗
生物化学
有机化学
共聚物
医学
生物
水溶液
生物技术
外科
内科学
聚合物
作者
Liang Chen,Liu Cao,Mengsi Zhan,Jin Li,Dayuan Wang,Régis Laurent,Serge Mignani,Anne‐Marie Caminade,Jean Pierre Majoral,Xiangyang Shi
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2022-06-13
卷期号:23 (7): 2827-2837
被引量:12
标识
DOI:10.1021/acs.biomac.2c00197
摘要
Conventional small molecular chemical drugs always have challenging limitations in cancer therapy due to their high systemic toxicity and low therapeutic efficacy. Nanotechnology has been applied in drug delivery, bringing new promising potential to realize effective cancer treatment. In this context, we develop here a new nanomicellar drug delivery platform generated by amphiphilic phosphorus dendrons (1-C17G3.HCl), which could form micelles for effective encapsulation of a hydrophobic anticancer drug doxorubicin (DOX) with a high drug loading content (42.4%) and encapsulation efficiency (96.7%). Owing to the unique dendritic rigid structure and surface hydrophilic groups, large steady void space of micelles can be created for drug encapsulation. The created DOX-loaded micelles with a mean diameter of 26.3 nm have good colloidal stability. Strikingly, we show that the drug-free micelles possess good intrinsic anticancer activity and act collectively with DOX to take down breast cancer cells in vitro and the xenografted tumor model in vivo through upregulation of Bax, PTEN, and p53 proteins for enhanced cell apoptosis. Meanwhile, the resulting 1-C17G3.HCl@DOX micelles significantly abolish the toxicity relevant to the free drug. The findings of this study demonstrate a unique nanomicelle-based drug delivery system created with the self-assembling amphiphilic phosphorus dendrons that may be adapted for chemotherapy of different cancer types.
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