Studies Concerning the Importance of Mononuclear Cells in the Development of Experimental Hepatitis

Summary Transfer of lymphocytes from C57B1 inbred mice with experimentally induced liver damage was made into normal isologous mice. Transferred lymphocytes may lead to infiltration of the periportal fields with mononuclear cells, and to an increase of Kupffer cells in the livers of recipients in a rather high percentage. No significant difference could be observed between animals treated with lymphocytes of mice poisoned with carbon tetrachloride or treated with lymphocytes from mice that had been sensitized to homologous liver extract given in Freund's adjuvant. Controls which had received lymphocytes from normal animals showed no liver injury as determined histologically.