Analysis of lymphocyte subsets in 73 patients with systemic lupus erythematosus

Objective To investigate the changes of T lymphocyte subsets,B cells and natural killer cells(NKcells) of peripheral blood in the patients with systemic lupus erythematosus(SLE).Methods Lymphocyte subsets of peripherial blood in 73 cases of SLE and 25 healthy famale controls were tested with flow cytometry.Results Compared with the female control group,97.3% cases of SLE reveled the lymphocyte subsets abnormality.CD3+CD4+cells were significantly decreased(P0.01),CD3+CD8+ cells were significantly increased(P0.01),CD3+CD4+/CD3+CD8+ ratio was decreased and inverted(P0.01),CD19+ cells were significantly decreased(P0.05).Conclusion Immunologic function is abnomal in SLE patients.