Huge hepatocellular carcinoma which holds a large proportion in clinic is a challenge problem for liver surgeons.Solitary huge hepatocellular carcinoma,a subtype of huge hepatocellular carcinoma,has special clinical and biological characters and good outcome after surgical resection.Surgical resection should be the first choice for solitary huge hepatocellular carcinoma,even though operation is extremely difficult due to its huge size.Surgical resection for solitary huge hepatocellular carcinoma is safe and feasible if surgeons are familiar with the operative indications and operation technique,which could improve the effects of surgical resection and decrease the incidence of complications.