Investigate applicability of midazolam and propofol on sedative of patients with mechanical ventilation in ICU

Objective To investigate applicability and effect of midazolam and propofol on sedative of patients with mechanical ventilation in ICU.Methods 96 cases of patients with sedative treatment were selected and randomly divided into midazolam groups and propofol groups,effect of sedative,onset time and awakening time were contrasted between midazolam groups and propofol groups.Results maintenance dosage was lower in midazolam groups than in propofol groups(P0.05),adjust number of medicine was identical between midazolam groups and propofol groups,onset time and awakening time were longer in midazolam groups than in propofol groups(P0.05).Conclusions propofol was suitable to applied in short term sedative and midazolam was suitable to applied in long-playing sedative,and should be discriminate in sedative treatment on patients in ICU.