牙周膜干细胞
生物
干细胞
细胞生物学
细胞外基质
细胞分化
牙周纤维
碱性磷酸酶
遗传学
牙科
医学
生物化学
基因
酶
作者
Xingsheng Zhao,Zongping Xie,Nanquan Rao,Shu Zhang,Yunpeng Zhang
出处
期刊:Gene
[Elsevier]
日期:2023-03-01
卷期号:858: 147185-147185
标识
DOI:10.1016/j.gene.2023.147185
摘要
Human periodontal ligament stem cells (hPDLSCs) are promising seed cells for oral bone tissue engineering. Dermatopontin (DPT) is a small-molecule protein recognized as a non-collagenous component of the extracellular matrix and is associated with a variety of biological processes. In this study, we first determined that DPT was elevated during the osteogenic differentiation of hPDLSCs. HPDLSCs interfering with DPT expression were established by lentiviral infection. It was found that the proliferation and osteogenic differentiation ability of hPDLSCs were inhibited after interfering DPT with lentivirus. Exogenous recombinant DPT treatment could not alter the proliferation of hPDLSCs. Coincidentally, exogenous DPT can only enhance the osteogenic differentiation of hPDLSCs in the control lentivirus group, but had no significant effect on the DPT interference group. This study expands the understanding of DPT function and implicates DPT as an important target for enhancing osteogenic differentiation of hPDLSCs.
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