Intracoronary delivery of extracellular vesicles from human cardiac progenitor cells reduces infarct size in porcine acute myocardial infarction

Journal Article Intracoronary delivery of extracellular vesicles from human cardiac progenitor cells reduces infarct size in porcine acute myocardial infarction Get access Maximilian Y Emmert, Maximilian Y Emmert Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charite (DHZC), Augustenburger Platz 1, 13353 Berlin, GermanyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyBIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyInstitute for Regenerative Medicine (IREM), University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland Corresponding authors. Tel: +49 30 4593 2030, Email: maximilian.emmert@dhzc-charite.de (M.Y.E); Tel: +41 91 811 7115, Email: giuseppe.vassalli@eoc.ch (G.V.) https://orcid.org/0000-0002-8837-1716 Search for other works by this author on: Oxford Academic PubMed Google Scholar Jacopo Burrello, Jacopo Burrello Department of Medical Sciences, University of Turin, Via Giuseppe Verdi 8, 10124 Turin, Italy https://orcid.org/0000-0001-7884-7314 Search for other works by this author on: Oxford Academic PubMed Google Scholar Petra Wolint, Petra Wolint Division of Surgical Research, University Hospital Zurich, University of Zurich, Sternwartstrasse 14, 8091 Zurich, Switzerland https://orcid.org/0000-0002-9978-1438 Search for other works by this author on: Oxford Academic PubMed Google Scholar Monika Hilbe, Monika Hilbe Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 268, 8057 Zurich, Switzerland https://orcid.org/0000-0002-4133-2402 Search for other works by this author on: Oxford Academic PubMed Google Scholar Gabriella Andriolo, Gabriella Andriolo Lugano Cell Factory, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale, Via Tesserete 48, 6900 Lugano, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Carolina Balbi, Carolina Balbi Laboratory of Cellular and Molecular Cardiology, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale, Via Tesserete 48, 6900 Lugano, SwitzerlandCenter for Molecular Cardiology, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland https://orcid.org/0000-0002-7394-1173 Search for other works by this author on: Oxford Academic PubMed Google Scholar Elena Provasi, Elena Provasi Lugano Cell Factory, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale, Via Tesserete 48, 6900 Lugano, Switzerland https://orcid.org/0000-0003-4073-1564 Search for other works by this author on: Oxford Academic PubMed Google Scholar Lucia Turchetto, Lucia Turchetto Lugano Cell Factory, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale, Via Tesserete 48, 6900 Lugano, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Marina Radrizzani, Marina Radrizzani Lugano Cell Factory, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale, Via Tesserete 48, 6900 Lugano, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Timo Z Nazari-Shafti, Timo Z Nazari-Shafti Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charite (DHZC), Augustenburger Platz 1, 13353 Berlin, GermanyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyBIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany https://orcid.org/0000-0002-9055-6891 Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more Nikola Cesarovic, Nikola Cesarovic Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charite (DHZC), Augustenburger Platz 1, 13353 Berlin, GermanyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyBIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Health Sciences and Technology, ETH Zurich, Rämistrasse 101, 8092 Zurich, Switzerland https://orcid.org/0000-0001-6744-2928 Search for other works by this author on: Oxford Academic PubMed Google Scholar Sebastian Neuber, Sebastian Neuber Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charite (DHZC), Augustenburger Platz 1, 13353 Berlin, GermanyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyBIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany https://orcid.org/0000-0003-1833-8440 Search for other works by this author on: Oxford Academic PubMed Google Scholar Volkmar Falk, Volkmar Falk Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charite (DHZC), Augustenburger Platz 1, 13353 Berlin, GermanyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Health Sciences and Technology, ETH Zurich, Rämistrasse 101, 8092 Zurich, Switzerland https://orcid.org/0000-0002-7911-8620 Search for other works by this author on: Oxford Academic PubMed Google Scholar Simon P Hoerstrup, Simon P Hoerstrup Institute for Regenerative Medicine (IREM), University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Rayyan Hemetsberger, Rayyan Hemetsberger Department of Cardiology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria Search for other works by this author on: Oxford Academic PubMed Google Scholar Mariann Gyöngyösi, Mariann Gyöngyösi Department of Cardiology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria https://orcid.org/0000-0002-7083-2107 Search for other works by this author on: Oxford Academic PubMed Google Scholar Lucio Barile, Lucio Barile Laboratory for Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale, Via Tesserete 48, 6900 Lugano, SwitzerlandFaculty of Biomedical Sciences, Università della Svizzera italiana (USI), Via Buffi 13, 6900 Lugano, Switzerland https://orcid.org/0000-0002-5827-0439 Search for other works by this author on: Oxford Academic PubMed Google Scholar Giuseppe Vassalli Giuseppe Vassalli Laboratory of Cellular and Molecular Cardiology, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale, Via Tesserete 48, 6900 Lugano, SwitzerlandCenter for Molecular Cardiology, University of Zurich, Wagistrasse 12, 8952 Schlieren, SwitzerlandFaculty of Biomedical Sciences, Università della Svizzera italiana (USI), Via Buffi 13, 6900 Lugano, Switzerland Corresponding authors. Tel: +49 30 4593 2030, Email: maximilian.emmert@dhzc-charite.de (M.Y.E); Tel: +41 91 811 7115, Email: giuseppe.vassalli@eoc.ch (G.V.) https://orcid.org/0000-0002-6378-5883 Search for other works by this author on: Oxford Academic PubMed Google Scholar European Heart Journal, ehad636, https://doi.org/10.1093/eurheartj/ehad636 Published: 03 October 2023 Article history Received: 12 December 2022 Revision received: 03 July 2023 Accepted: 11 September 2023 Published: 03 October 2023