Lupiwighteone Ameliorates Diabetic Nephropathy-Induced Renal Fibrosis via SIRT1/NF-κB Signaling Pathway-Mediated Inflammatory Response

mice. In vitro, lupiwighteone activated SIRT1 in high glucose-treated HK-2 cells, suppressed NF-κB signaling, and decreased fibrosis markers. Collectively, lupiwighteone ameliorates DN-induced renal fibrosis via the SIRT1/NF-κB pathway, highlighting its potential as a dietary supplement for preventing renal fibrosis in DN.