Hyperfusion: A hypernetwork approach to multimodal integration of tabular and medical imaging data for predictive modeling

The integration of diverse clinical modalities such as medical imaging and the tabular data extracted from patients’ Electronic Health Records (EHRs) is a crucial aspect of modern healthcare. Integrative analysis of multiple sources can provide a comprehensive understanding of the clinical condition of a patient, improving diagnosis and treatment decision. Deep Neural Networks (DNNs) consistently demonstrate outstanding performance in a wide range of multimodal tasks in the medical domain. However, the complex endeavor of effectively merging medical imaging with clinical, demographic and genetic information represented as numerical tabular data remains a highly active and ongoing research pursuit. We present a novel framework based on hypernetworks to fuse clinical imaging and tabular data by conditioning the image processing on the EHR’s values and measurements. This approach aims to leverage the complementary information present in these modalities to enhance the accuracy of various medical applications. We demonstrate the strength and generality of our method on two different brain Magnetic Resonance Imaging (MRI) analysis tasks, namely, brain age prediction conditioned by subject’s sex and multi-class Alzheimer’s Disease (AD) classification conditioned by tabular data. We show that our framework outperforms both single-modality models and state-of-the-art MRI tabular data fusion methods. A link to our code can be found at https://github.com/daniel4725/HyperFusion . • We present a HyperFusion network - a novel hypernetwork for medical imaging and tabular data fusion. • A hypernetwork controls a primary network by producing parameters to predefined layers. • This mechanism is exploited to condition image processing predictions by tabular data. • The HyperFusion outperforms existing imaging-tabular fusion methods for Alzheimer’s disease classification. • The HyperFusion versatility is demonstrated for brain age prediction conditioned by sex.