Preparation of N ‐Trifluoromethylthiosaccharin: A Shelf‐Stable Electrophilic Reagent for Trifluoromethylthiolation

Abstract Procedures yielding N ‐chlorosaccharin ( 2 ) as a white powder, tris‐silver (I) trifluoromethanethiolate ( 3 ) as an off‐white solid, and N ‐trifluoromethylthiosaccharin ( 4 ) as a white solid are presented. The chapter concludes with a discussion on trifluoromethylthio group as one of the most “sought‐after” fluoroalkyl groups, owing to its high lipophilicity.