炎症
免疫系统
神经科学
中枢神经系统
医学
有害刺激
神经胶质
慢性疼痛
机制(生物学)
小胶质细胞
免疫学
伤害
生物
受体
内科学
哲学
认识论
作者
Hongji Wang,Chao-Jiang Xu
标识
DOI:10.1021/acschemneuro.1c00607
摘要
Inflammatory pain is the perception of noxious stimuli that occurs during inflammation or an immune response. Glial cells are widespread in the central and peripheral nervous systems, supporting and guiding the migration of neurons, participating in the immune response, forming the myelin sheath and blood-brain barrier, and maintaining the concentration of potassium ions outside nerve cells. Recent studies have shown that glial cells have a significant connection with the production and development of inflammatory pain. This article reviews the relationship, mechanisms, therapeutic targets between five types of glial cells and inflammatory pain, and the medicine composition that can effectively inhibit inflammatory pain. It expands the study on the mechanism of glial cells regulating pain and provides new ideas for the therapy of inflammatory pain.
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