骨骼肌
河马信号通路
调节器
细胞生物学
效应器
生物
转录因子
肌萎缩
肌肉萎缩
肌肉肥大
心肌细胞
解剖
内分泌学
遗传学
基因
作者
Kevin I. Watt,Bradley J. Turner,Adam Hagg,Xuehua Zhang,Jonathan R. Davey,Hongwei Qian,Claudia Beyer,Catherine E. Winbanks,Kieran F. Harvey,Paul Gregorevic
摘要
The Yes-associated protein (YAP) is a core effector of the Hippo pathway, which regulates proliferation and apoptosis in organ development. YAP function has been extensively characterized in epithelial cells and tissues, but its function in adult skeletal muscle remains poorly defined. Here we show that YAP positively regulates basal skeletal muscle mass and protein synthesis. Mechanistically, we show that YAP regulates muscle mass via interaction with TEAD transcription factors. Furthermore, YAP abundance and activity in muscles is increased following injury or degeneration of motor nerves, as a process to mitigate neurogenic muscle atrophy. Our findings highlight an essential role for YAP as a positive regulator of skeletal muscle size. Further investigation of interventions that promote YAP activity in skeletal muscle might aid the development of therapeutics to combat muscle wasting and neuromuscular disorders. The Yes-associated protein (YAP) is a core effector of the Hippo pathway, which regulates proliferation and apoptosis in organ development, but its function in adult skeletal muscle remains poorly defined. Here the authors show that YAP is an essential regulator of myofibre size in adult skeletal muscle, via interaction with TEAD transcription factors.
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