氧化呋咱环
药效团
部分
化学
前药
组合化学
一氧化氮
立体化学
有机化学
生物化学
作者
Elena Chugunova,А. Р. Бурилов
标识
DOI:10.2174/1568026616666160927145822
摘要
Hybrid drug strategy is based on the combination of two or more pharmacophores into a new chemical entity to improve the properties of the original compounds or to obtain double action of resulting molecule. Hybrid molecules, comprised of some pharmacophore and nitric oxide (NO) donor moiety, constitute one of the more promising approaches for the design of drugs. Furoxans and benzofuroxans are considered NO releasing prodrugs and are of great interest for researchers. In this review we will focus on furoxan and benzofuroxan hybrids described in literature during the last years (from 2005 to 2016). Keywords: Furoxan, Benzofuroxan, NO-donor, Hybrid, Pharmacophore.
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