Pharmacological Effects of Shuangshen Rougan Keli on Experimental Hepatic Cirrhosis in Rats

Shuangshen Rougan Keli (SS) could effectively blocked the formation of hepatic cirrhosis in rats induced by complex pathogenic causes. Both the two treating groups could restore enzyme activity level. The content of r-GT,SGPT and SGOT in serum decreased from 345±95 nmol/s to 200±21 nmol/s. It could enhance collagen excretion and inhibit fibrin proliferation. Hydroxyproline excretion increased in urine, and decreased in hepatic and decreased in serum. In addition, SS could also clear the storage of triglyceride in the liver. Lower MDA and elevate the activity of SOD. It is suggested that SS has marked effects on enhancing the restoration of damaged hepatic histocytes, on retarding hepatic adipogenesis and necrosis, and on interrupting the derelopment of chronic hepatic cirrhosis.