血清学
梅毒
医学
梅毒血清诊断
骨髓瘤蛋白
免疫学
多发性骨髓瘤
抗体
人类免疫缺陷病毒(HIV)
作者
Taiping He,Fan Mo,Xiao-You Xiao,Qiao-Yun Dan,Su-Jie Li,Yinhui Zhang,Xuedong Lu
出处
期刊:PubMed
日期:2016-04-01
卷期号:24 (2): 478-81
被引量:3
标识
DOI:10.7534/j.issn.1009-2137.2016.02.032
摘要
The false positive in conventional syphilis serological test was found in patients with multiple myeloma (MM).To investigate the relationship between the M-protein of patients with MM and the false positive in conventional syphilis serologic test.The M-protein of 68 MM cases was typed with immunofixation electrophoresis and 68 cases of MM were screened with non-specific and specific syphilis serologic tests, then the samples with syphilic serological positive were chosen and confirmed with immonobloting test, finally the relationship between M protein of MM and the false positive of syphilis serological test were analysed.Four out of 68 cases showed the positive in syphilis serological test and further were confimed to be false positive by immunoblotting test, the false positive rate was nearly 6%. The M-protein of MM patients in our hospital mostly possessed IgG, κ type, followed by IgA, κ type, light chain κ type. In general, κ : λ = 2.4 : 1. Among samples of 4 cases with syphilis serological positive 2 cases were of IgG and κ type, 1 case was of IgG, λ type, another 1 case was IgA, κ type.The M-protein of IgG and IgA types in MM patients results in syphilis serological false positive reaction. The clinicians and laboratorial technicians should pay a great attention to screen the MM patients for the false positive syphilis serological test so as to avoid the misdiagnosis and subsequent embarassment.
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