Objective To evaluate the significance of the double balloon endoscopy and capsule endoscopy in the diagnosis of obscure gastrointestinal bleeding.Methods From October 2006 to November 2008,there were 354 patients(214 men,140 women;mean age of 49.9 years,range 13-88 years) with obscure gastrointestinal bleeding;152 patients were performed double balloon endoscopy and 202 were performed capsule endoscopy.Results The bleeding sources were identified with a positive rate of 82.24%(125/152) and 71.78%(145/202) respectively by double balloon endoscopy and capsule endoscopy.The etiological diagnostic accuracy of double balloon endoscopy was 85.1%,and 31.2% for capsule endoscopy.All patients were well tolerated except 2 did not accomplish capsule endoscopy.Conclusion Double balloon endoscopy and capsule endoscopy are both effective and safe method for the diagnosis of obscure gastrointestinal bleeding.But double balloon endoscopy is superior to capsule endoscopy in the diagnostic yield and the etiological diagnosis.