Versatile 2-Oxoglutarate-Dependent Dioxygenases Catalyze Radical-Mediated Multifunctional Skeleton Reconstructions and Oxidation Modifications of Taxoids

-5/7/6 taxoids showed effective tumor resistance reversal activity. Our findings offered new insights into the formation of taxane structural diversity, expanded the chemical space of taxane diterpenoids, and provided valuable biocatalytic tools for constructing unusual taxane architectures through enzyme engineering or synthetic biology.