冗余(工程)
轴突引导
环岛
计算机科学
受体
化学
生物
神经科学
生物化学
操作系统
作者
Alexander Jaworski,Irene Tom,Raymond K. Tong,Holly K. Gildea,Alexander W. Koch,Lino C. Gonzalez,Marc Tessier‐Lavigne
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2015-11-20
卷期号:350 (6263): 961-965
被引量:92
标识
DOI:10.1126/science.aad2615
摘要
Axon pathfinding is orchestrated by numerous guidance cues, including Slits and their Robo receptors, but it remains unclear how information from multiple cues is integrated or filtered. Robo3, a Robo family member, allows commissural axons to reach and cross the spinal cord midline by antagonizing Robo1/2-mediated repulsion from midline-expressed Slits and potentiating deleted in colorectal cancer (DCC)-mediated midline attraction to Netrin-1, but without binding either Slits or Netrins. We identified a secreted Robo3 ligand, neural epidermal growth factor-like-like 2 (NELL2), which repels mouse commissural axons through Robo3 and helps steer them to the midline. These findings identify NELL2 as an axon guidance cue and establish Robo3 as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits Slit repulsion, and facilitates Netrin attraction to achieve a common guidance purpose.
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