自噬
PI3K/AKT/mTOR通路
骨关节炎
下调和上调
医学
炎症
p38丝裂原活化蛋白激酶
蛋白激酶B
细胞生物学
癌症研究
体内
信号转导
药理学
化学
细胞凋亡
免疫学
生物
病理
MAPK/ERK通路
基因
生物化学
替代医学
生物技术
作者
Jiyuan Yan,Bowei Ni,Gaohong Sheng,Yingchi Zhang,Yifan Xiao,Yongzhuang Ma,Hao Li,Hua Wu,Chen Tu
标识
DOI:10.3389/fphar.2021.661072
摘要
Osteoarthritis (OA) is a common age-related joint disease. Its development has been generally thought to be associated with inflammation and autophagy. Rhoifolin (ROF), a flavanone extracted from Rhus succedanea , has exhibited prominent anti-oxidative and anti-inflammatory properties in several diseases. However the exact role of ROF in OA remains unclear. Here, we investigated the therapeutic effects as well as the underlying mechanism of ROF on rat OA. Our results indicated that ROF could significantly alleviate the IL-1β–induced inflammatory responses, cartilage degradation, and autophagy downregulation in rat chondrocytes. Moreover, administration of autophagy inhibitor 3-methyladenine (3-MA) could reverse the anti-inflammatory and anti-cartilage degradation effects of ROF. Furthermore, P38/JNK and PI3K/AKT/mTOR signal pathways were involved in the protective effects of ROF. In vivo , intra-articular injection of ROF could notably ameliorate the cartilage damage in rat OA model. In conclusion, our work elucidated that ROF ameliorated rat OA via regulating autophagy, indicating the potential role of ROF in OA therapy.
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