EML4-ALK fusion gene in non-small cell lung cancer

EML4-ALK fusion gene can improve the expression of anaplastic lymphoma kinase ALK） protein and activate ALK inducing tumor cells proliferation and anti-apoptosis. EML4-ALK fusion genem nonsmall-cell lung cancer which has unique clinical and pathological features is more common in young femal, never smokers, and adenocarcinoma patients, At present, EMIA-ALK fusion gene can be detected using RT-PCR, FISH and IHC. Crizotinib, an ALK inhibitor, can block the gene＇s signal pathway and restrain tumor＇s activity. Key words: Carcinoma, non-small-cell lung ;  Gene fusion ;  Molecular diagnostic techniques