生物利用度
激素
梗塞
医学
氧化应激
内科学
甲状腺激素
药理学
心肌梗塞
过氧化氢酶
内分泌学
作者
Alexandre Luz de Castro,Rafael Oliveira Fernandes,Vanessa Duarte Ortiz,Cristina Campos Carraro,Jéssica Hellen Poletto Bonetto,Tânia Regina Gattelli Fernandes,Adriana Conzatti,Rafaela Siqueira,Angela Vicente Tavares,Adriane Belló‐Klein
标识
DOI:10.1080/13813455.2020.1779752
摘要
Infarction leads to a decrease in NO bioavailability in the erythrocytes. Thyroid hormones (TH) present positive effects after infarction. However, there are no studies evaluating the effects of cardioprotective doses of TH in the erythrocytes after infarction.This study aimed to evaluate the effects of TH in NO bioavailability and oxidative stress parameters in the erythrocytes of infarcted rats.Wistar rats were allocated into the three groups: Sham-operated (SHAM), infarcted (AMI) and infarcted + TH (AMIT). AMIT rats received T4 and T3 for 12 days by gavage. Subsequently, the animals were evaluated by echocardiography and the LV and erythrocytes were collected.TH improved NO bioavailability and increased catalase activity in the erythrocytes. Besides that, TH increased HIF-1α in the heart.TH seems to be positive for erythrocytes preventing a decrease in NO bioavailability and increasing antioxidant enzymatic defense after infarction.
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