心力衰竭
酮体
内科学
心脏病
蛋白质水解
心脏病学
人的心脏
代谢组学
化学
生物化学
医学
新陈代谢
色谱法
酶
作者
Danielle Murashige,Cholsoon Jang,Michael D. Neinast,Jonathan J. Edwards,Alexis Cowan,Matthew C. Hyman,Joshua D. Rabinowitz,David S. Frankel,Zoltàn Arany
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2020-10-16
卷期号:370 (6514): 364-368
被引量:283
标识
DOI:10.1126/science.abc8861
摘要
Metabolomics, at the heart With heart failure a leading cause of death, a better understanding of metabolic function in the heart is a welcome advance. Murashige et al. measured more than 270 metabolites using liquid chromatography–mass spectrometry in human blood samples taken from an artery entering the heart and from a vein leaving it. Differences thus reflected the metabolic processes at work in the heart. Their results confirmed that hearts voraciously consume fatty acids. Hearts secreted, rather than consumed, amino acids, thus revealing active proteolysis. In patients with heart failure, ketone and lactate consumption increased, as did proteolysis. These findings could lead to strategies for fighting heart disease by altering metabolism. Science , this issue p. 364
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